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Robert H. Rice
 
 
UC Davis Cancer Center
Professor, UCD, AES, Env Toxicology
rhrice@ucdavis.edu
UC Berkeley, Molecular Biology, PhD, 1967 - 1972
UC Davis, Protein Chemistry, Postdoctoral Fellow, 1972 - 1975
MIT, Cell Biology, Postdoctoral Fellow, 1975 - 1979
UC Davis, Environmental Toxicology, Professor, 1991

Keratinocytes Research The main goals of Dr. Rice's research are to understand how various types of keratinocytes (epidermal cells) mature, the mechanisms by which regulation of their maturation is disturbed by toxic agents, and the signaling pathways by which toxic agents and carcinogens disturb this cell type. To this end, the lab measures expression of specific differentiation markers and their perturbation by agents such as metals, food mutagens and combustion products (polycyclic aromatic hydrocarbons, dioxin). The results may help in predicting the response of epidermis and other epithelia to toxic substances and in extrapolating data from rodent toxicity/carcinogenicity testing to human responses to such agents.

Research Areas Toxicology, Molecular Cell Biology

Selected Publications

Patterson TJ, Reznikova TV, Phillips MA, Rice RH. Arsenic preserves germinative state in cultured human epidermal cells. Toxicol Appl Pharmacol. 203: (0) in press. (2005)
Phillips MA, Jessen BA, Lu Y, Qin Q, Stevens ME, Rice RH. A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes. BMC Dermatol. 4: (1) 2. (2004)
Monk SA, Denison MS, Rice RH. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys. 419:: (0) 158-169. (2003)
Rea MA, Gregg JP, Qin Q, Phillips MA, Rice RH. Global alteration of gene expression in human keratinocytes by inorganic arsenic. Carcinogenesis. 24:: (0) 747-756. (2003)
Patterson TJ, Ngo M, Aronov PA, Reznikova TV, Green PG, Rice RH. Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes. Chem Res Toxicol. 16: (12) 1624 - 1631. (2003)