Andrew T. Vaughan
UC Davis Cancer Center
Radiobiologist, UCD, Med, Radiation Oncology
andrew.vaughan@ucdmc.ucdavis.edu
Birmingham Univ, Applied Nuclear Physics, PhD, 1979
UC Davis, Rad Onc, Professor, 2004
Research Interests
Dr. Vaughan's research is focused on a novel pathological role for apoptosis where he proposes that rare cells have the capacity to survive limited exposure to the DNA cleavage stage of apoptosis. Such cells may inherit DNA aberrations, such as translocations, that provide the initiating event for neoplastic transformation.
Research Areas
Apoptosis, Cell Cycle, Leukemia
Selected Publications
Vaughan AT, Betti CJ, Villalobos MJ, Premkumar K, Cline E, Jiang Q, Diaz MO. Surviving apoptosis: A possible mechanism of benzene-induced leukemia.
Chem Biol Interact.
153-154: (0) 179-85. (2005)
Betti CJ, Villalobos MJ, Diaz MO, Vaughan AT. Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division.
Cancer Res.
63: (6) 1377-81. (2003)
Andrew T. Vaughan